HEALTH SCIENCES COLLABORATIVE CENTER FOR PROTEOMICS

Proteomics has come of age! Dr. Gonzalez is the Founding Director for the Health Sciences Proteomics Center at UCSD. The center has operated successfully for over 11 years using a Thermo Orbitrap Fusion and has recently acquired a state-of-the-art Thermo Scientific Orbitrap Astral mass spectrometer. This state-of-the-art instrument combines speed, precision, and deeper proteome coverage to deliver unparalleled results. The Thermo Scientific Orbitrap Astral MS can quantify five times as many peptides per unit time as other Thermo Scientific mass spectrometers. These advances will aid projects by offering unparalleled sensitivity and resolution of proteins, quick turnaround times, high-confidence results, enhanced capacity to analyze large sample cohorts, and unbiased insights into cellular functions, including biologically significant posttranslational modifications. Dr. Gonzalez has collaborated with several researchers to perform proteomics science to the highest standards, as demonstrated by the work of Markmiller et al. Cell 2018 (PMID: 29373831), Wozniak et al. Cell 2020 (PMID: 32888495), Russel et al. Cell 2022 (PMID: 35931082), Buzan et al. Cell Host & Microbe 2023 (PMID: 38228143), Fallon et al. Science 2024 (PMID: 39116217), Mills et al. Nature Microbiology 2022 (PMID: 35087228) and Gu et al. Nature 2025 (PMID: 39743585). Notably, advances in throughput have driven down the cost of proteomics, making it competitive with genomics and RNA-seq.

 

 

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​​​​​​​​​​​Please contact Dr. Gonzalez for pricing: djgonzalez@health.ucsd.edu